Constraining the cosmic radiation density due to lepton number with Big Bang Nucleosynthesis

The cosmic energy density in the form of radiation before and during Big Bang Nucleosynthesis (BBN) is typically parameterized in terms of the effective number of neutrinos N_eff. This quantity, in case of no extra degrees of freedom, depends upon the chemical potential and the temperature characterizing the three active neutrino distributions, as well as by their possible non-thermal features. In the present analysis we determine the upper bounds that BBN places on N_eff from primordial neutrino--antineutrino asymmetries, with a careful treatment of the dynamics of neutrino oscillations. We consider quite a wide range for the total lepton number in the neutrino sector, eta_nu= eta_{nu_e}+eta_{nu_mu}+eta_{nu_tau} and the initial electron neutrino asymmetry eta_{nu_e}^in, solving the corresponding kinetic equations which rule the dynamics of neutrino (antineutrino) distributions in phase space due to collisions, pair processes and flavor oscillations. New bounds on both the total lepton number in the neutrino sector and the nu_e -bar{nu}_e asymmetry at the onset of BBN are obtained fully exploiting the time evolution of neutrino distributions, as well as the most recent determinations of primordial 2H/H density ratio and 4He mass fraction. Note that taking the baryon fraction as measured by WMAP, the 2H/H abundance plays a relevant role in constraining the allowed regions in the eta_nu -eta_{nu_e}^in plane. These bounds fix the maximum contribution of neutrinos with primordial asymmetries to N_eff as a function of the mixing parameter theta_13, and point out the upper bound N_eff < 3.4. Comparing these results with the forthcoming measurement of N_eff by the Planck satellite will likely provide insight on the nature of the radiation content of the universe.Comment: 17 pages, 9 figures, version to be published in JCA

Development of an immunosensor for PfHRP 2 as a biomarker for Malaria detection

Plasmodium falciparum histidine-rich protein 2 (PfHRP 2) was selected in this work as the biomarker for the detection and diagnosis of malaria. An enzyme-linked immunosorbent assay (ELISA) was first developed to evaluate the immunoreagent’s suitability for the sensor’s development. A gold-based sensor with an integrated counter and an Ag/AgCl reference electrode was first selected and characterised and then used to develop the immunosensor for PfHRP 2, which enables a low cost, easy to use, and sensitive biosensor for malaria diagnosis. The sensor was applied to immobilise the anti-PfHRP 2 monoclonal antibody as the capture receptor. A sandwich ELISA assay format was constructed using horseradish peroxidase (HRP) as the enzyme label, and the electrochemical signal was generated using a 3, 3′, 5, 5′tetramethyl-benzidine dihydrochloride (TMB)/H2O2 system. The performance of the assay and the sensor were optimised and characterised, achieving a PfHRP 2 limit of detection (LOD) of 2.14 ng·mL−1 in buffer samples and 2.95 ng∙mL−1 in 100% spiked serum samples. The assay signal was then amplified using gold nanoparticles conjugated detection antibody-enzyme and a detection limit of 36 pg∙mL−1 was achieved in buffer samples and 40 pg∙mL−1 in serum samples. This sensor format is ideal for malaria detection and on-site analysis as a point-of-care device (POC) in resource-limited settings where the implementation of malaria diagnostics is essential in control and elimination efforts

Increasing Neff with particles in thermal equilibrium with neutrinos

Recent work on increasing the effective number of neutrino species (Neff) in the early universe has focussed on introducing extra relativistic species (`dark radiation'). We draw attention to another possibility: a new particle of mass less than 10 MeV that remains in thermal equilibrium with neutrinos until it becomes non-relativistic increases the neutrino temperature relative to the photons. We demonstrate that this leads to a value of Neff that is greater than three and that Neff at CMB formation is larger than at BBN. We investigate the constraints on such particles from the primordial abundance of helium and deuterium created during BBN and from the CMB power spectrum measured by ACT and SPT and find that they are presently relatively unconstrained. We forecast the sensitivity of the Planck satellite to this scenario: in addition to dramatically improving constraints on the particle mass, in some regions of parameter space it can discriminate between the new particle being a real or complex scalar.Comment: 10 pages, 5 figures v2 matches version to appear in JCA

Mapping systematic errors in helium abundance determinations using Markov Chain Monte Carlo

Monte Carlo techniques have been used to evaluate the statistical and systematic uncertainties in the helium abundances derived from extragalactic H~II regions. The helium abundance is sensitive to several physical parameters associated with the H~II region. In this work, we introduce Markov Chain Monte Carlo (MCMC) methods to efficiently explore the parameter space and determine the helium abundance, the physical parameters, and the uncertainties derived from observations of metal poor nebulae. Experiments with synthetic data show that the MCMC method is superior to previous implementations (based on flux perturbation) in that it is not affected by biases due to non-physical parameter space. The MCMC analysis allows a detailed exploration of degeneracies, and, in particular, a false minimum that occurs at large values of optical depth in the He~I emission lines. We demonstrate that introducing the electron temperature derived from the [O~III] emission lines as a prior, in a very conservative manner, produces negligible bias and effectively eliminates the false minima occurring at large optical depth. We perform a frequentist analysis on data from several "high quality" systems. Likelihood plots illustrate degeneracies, asymmetries, and limits of the determination. In agreement with previous work, we find relatively large systematic errors, limiting the precision of the primordial helium abundance for currently available spectra.Comment: 25 pages, 11 figure

Searching for sterile neutrinos in ice

Oscillation interpretation of the results from the LSND, MiniBooNE and some other experiments requires existence of sterile neutrino with mass $\sim 1$ eV and mixing with the active neutrinos $|U_{\mu 0}|^2 \sim (0.02 - 0.04)$. It has been realized some time ago that existence of such a neutrino affects significantly the fluxes of atmospheric neutrinos in the TeV range which can be tested by the IceCube Neutrino Observatory. In view of the first IceCube data release we have revisited the oscillations of high energy atmospheric neutrinos in the presence of one sterile neutrino. Properties of the oscillation probabilities are studied in details for various mixing schemes both analytically and numerically. The energy spectra and angular distributions of the $\nu_\mu-$events have been computed for the simplest $\nu_s-$mass, and $\nu_s - \nu_\mu$ mixing schemes and confronted with the IceCube data. An illustrative statistical analysis of the present data shows that in the $\nu_s-$mass mixing case the sterile neutrinos with parameters required by LSND/MiniBooNE can be excluded at about $3\sigma$ level. The $\nu_s- \nu_\mu$ mixing scheme, however, can not be ruled out with currently available IceCube data.Comment: 41 pages, 16 figures. Accepted for publication in JHEP. Minor changes from the previous versio

Primordial Nucleosynthesis

Primordial nucleosynthesis, or Big-Bang Nucleosynthesis (BBN), is one of the three evidences for the Big-Bang model, together with the expansion of the Universe and the Cosmic Microwave Background. There is a good global agreement over a range of nine orders of magnitude between abundances of 4He, D, 3He and 7Li deduced from observations, and calculated in primordial nucleosynthesis. This comparison was used to determine the baryonic density of the Universe. For this purpose, it is now superseded by the analysis of the Cosmic Microwave Background (CMB) radiation anisotropies. However, there remain, a yet unexplained, discrepancy of a factor 3-5, between the calculated and observed lithium primordial abundances, that has not been reduced, neither by recent nuclear physics experiments, nor by new observations. We review here the nuclear physics aspects of BBN for the production of 4He, D, 3He and 7Li, but also 6Li, 9Be, 11B and up to CNO isotopes. These are, for instance, important for the initial composition of the matter at the origin of the first stars. Big-Bang nucleosynthesis, that has been used, to first constrain the baryonic density, and the number of neutrino families, remains, a valuable tool to probe the physics of the early Universe, like variation of "constants" or alternative theories of gravity.Comment: Invited Plenary Talk given at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS

Asymmetric Dark Matter and Dark Radiation

Asymmetric Dark Matter (ADM) models invoke a particle-antiparticle asymmetry, similar to the one observed in the Baryon sector, to account for the Dark Matter (DM) abundance. Both asymmetries are usually generated by the same mechanism and generally related, thus predicting DM masses around 5 GeV in order to obtain the correct density. The main challenge for successful models is to ensure efficient annihilation of the thermally produced symmetric component of such a light DM candidate without violating constraints from collider or direct searches. A common way to overcome this involves a light mediator, into which DM can efficiently annihilate and which subsequently decays into Standard Model particles. Here we explore the scenario where the light mediator decays instead into lighter degrees of freedom in the dark sector that act as radiation in the early Universe. While this assumption makes indirect DM searches challenging, it leads to signals of extra radiation at BBN and CMB. Under certain conditions, precise measurements of the number of relativistic species, such as those expected from the Planck satellite, can provide information on the structure of the dark sector. We also discuss the constraints of the interactions between DM and Dark Radiation from their imprint in the matter power spectrum.Comment: 22 pages, 5 figures, to be published in JCAP, minor changes to match version to be publishe

Isocurvature perturbations in extra radiation

Recent cosmological observations, including measurements of the CMB anisotropy and the primordial helium abundance, indicate the existence of an extra radiation component in the Universe beyond the standard three neutrino species. In this paper we explore the possibility that the extra radiation has isocurvatrue fluctuations. A general formalism to evaluate isocurvature perturbations in the extra radiation is provided in the mixed inflaton-curvaton system, where the extra radiation is produced by the decay of both scalar fields. We also derive constraints on the abundance of the extra radiation and the amount of its isocurvature perturbation. Current observational data favors the existence of an extra radiation component, but does not indicate its having isocurvature perturbation. These constraints are applied to some particle physics motivated models. If future observations detect isocurvature perturbations in the extra radiation, it will give us a hint to the origin of the extra radiation.Comment: 41 pages, 8 figures; version accepted for publication in JCA

Restrictions on the lifetime of sterile neutrinos from primordial nucleosynthesis

We analyze the influence of decaying sterile neutrinos with the masses in the range 1-140 MeV on the primordial Helium-4 abundance, explicitly solving the Boltzmann equations for all particle species, taking into account neutrino flavour oscillations, and paying special attention to systematic uncertainties. We show that the Helium abundance depends only on the sterile neutrino lifetime and not on the way the active-sterile mixing is distributed between flavours, and derive an upper bound on the lifetime. We also demonstrate that the recent results of Izotov & Thuan [arXiv:1001.4440], who find 2sigma higher than predicted by the standard primordial nucleosynthesis value of Helium-4 abundance, are consistent with the presence in the plasma of sterile neutrinos with the lifetime 0.01-2 seconds. The decay of these particles perturbs the spectra of (decoupled) neutrinos and heats photons, changing the ratio of neutrino to photon energy density, that can be interpreted as extra neutrino species at the recombination epoch.Comment: 17 pp. + Appendices. Analysis of deuterium bounds and more accurate account of CMB bounds on Helium-4 is added. Final version to appear in JCA

Cosmological bounds on sub-MeV mass axions

Axions with mass greater than 0.7 eV are excluded by cosmological precision data because they provide too much hot dark matter. While for masses above 20 eV the axion lifetime drops below the age of the universe, we show that the cosmological exclusion range can be extended from 0.7 eV till 300 keV, primarily by the cosmic deuterium abundance: axion decays would strongly modify the baryon-to-photon ratio at BBN relative to the one at CMB decoupling. Additional arguments include neutrino dilution relative to photons by axion decays and spectral CMB distortions. Our new cosmological constraints complement stellar-evolution limits and laboratory bounds.Comment: 19 pages, 10 figure